PARK2
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- aggresome assembly [IMP]
- cellular protein catabolic process [IMP]
- cellular response to dopamine [TAS]
- cellular response to manganese ion [TAS]
- cellular response to toxic substance [IMP]
- cellular response to unfolded protein [TAS]
- central nervous system development [TAS]
- dopamine metabolic process [TAS]
- mitochondrial fission [ISS]
- mitochondrion degradation [IMP, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell death [IDA]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of glucokinase activity [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IGI]
- negative regulation of oxidative stress-induced cell death [NAS, TAS]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of reactive oxygen species metabolic process [IGI]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- neuron cellular homeostasis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of proteasomal protein catabolic process [IGI]
- positive regulation of protein linear polyubiquitination [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K27-linked ubiquitination [TAS]
- protein K29-linked ubiquitination [TAS]
- protein K48-linked ubiquitination [IDA]
- protein K6-linked ubiquitination [TAS]
- protein K63-linked ubiquitination [IDA, TAS]
- protein autoubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IC, IDA, NAS, TAS]
- regulation of autophagy [IDA]
- regulation of cellular response to oxidative stress [ISS]
- regulation of dopamine secretion [TAS]
- regulation of glucose metabolic process [TAS]
- regulation of lipid transport [TAS]
- regulation of mitochondrion degradation [TAS]
- regulation of mitochondrion organization [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of synaptic vesicle transport [NAS]
- response to endoplasmic reticulum stress [IMP]
- response to oxidative stress [ISS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
ACTG1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adherens junction organization [TAS]
- axon guidance [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- membrane organization [TAS]
- platelet aggregation [IMP]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative interaction proteomics of neurodegenerative disease proteins.
Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protein (APP) and Presenilin-1 (PSEN1) for Alzheimer's disease (AD), Huntingtin (HTT) for Huntington's disease, Parkin (PARK2) for Parkinson's disease, and Ataxin-1 (ATXN1) for spinocerebellar ataxia type 1. Our network ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARK2 ACTG1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3463263 | |
| PARK2 ACTG1 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | - |
Curated By
- BioGRID