BAIT
CTNNB1
Catnb
catenin (cadherin associated protein), beta 1
GO Process (159)
GO Function (26)
GO Component (40)
Gene Ontology Biological Process
- Schwann cell proliferation [IMP]
- T cell differentiation [ISO]
- T cell differentiation in thymus [ISO]
- Wnt signaling pathway [ISO, ISS]
- adherens junction assembly [ISO, ISS]
- adherens junction organization [ISO]
- anterior/posterior axis specification [ISO]
- bone resorption [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- canonical Wnt signaling pathway [ISO, ISS]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISO]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [ISO, ISS]
- cell adhesion [ISO, ISS]
- cell differentiation [ISO]
- cell fate determination [ISO]
- cell fate specification [ISO]
- cell maturation [ISO]
- cell morphogenesis involved in differentiation [ISO]
- cell proliferation [ISO]
- cell-matrix adhesion [ISO]
- cellular process [ISO]
- cellular protein localization [ISO]
- cellular response to growth factor stimulus [ISO, ISS]
- cellular response to indole-3-methanol [ISO, ISS]
- cellular response to insulin-like growth factor stimulus [IEP, IMP]
- cellular response to mechanical stimulus [IDA]
- cellular response to organic cyclic compound [ISO]
- central nervous system vasculogenesis [ISO]
- chromatin-mediated maintenance of transcription [ISO]
- dorsal/ventral axis specification [ISO]
- dorsal/ventral pattern formation [ISO]
- ectoderm development [ISO]
- embryonic axis specification [ISO]
- embryonic digit morphogenesis [ISO]
- embryonic foregut morphogenesis [ISO]
- embryonic forelimb morphogenesis [ISO]
- embryonic heart tube development [ISO]
- embryonic hindlimb morphogenesis [ISO]
- embryonic skeletal limb joint morphogenesis [ISO]
- endoderm formation [ISO]
- endodermal cell fate commitment [ISO]
- endothelial tube morphogenesis [ISO, ISS]
- epithelial cell differentiation involved in prostate gland development [ISO]
- epithelial tube branching involved in lung morphogenesis [ISO]
- forebrain development [ISO]
- fungiform papilla formation [ISO]
- gastrulation with mouth forming second [ISO]
- genitalia morphogenesis [ISO]
- glial cell fate determination [ISO]
- hair cycle process [ISO]
- hair follicle morphogenesis [ISO]
- hair follicle placode formation [ISO]
- heart development [ISO]
- hemopoiesis [ISO]
- in utero embryonic development [ISO]
- kidney development [ISO]
- layer formation in cerebral cortex [ISO]
- lens morphogenesis in camera-type eye [ISO]
- limb development [ISO]
- liver development [IEP]
- lung cell differentiation [ISO]
- lung development [ISO]
- lung induction [ISO]
- lung-associated mesenchyme development [ISO]
- male genitalia development [ISO]
- mesenchymal cell proliferation involved in lung development [ISO]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [ISO]
- metanephros morphogenesis [ISO]
- midgut development [IEP]
- morphogenesis of embryonic epithelium [ISO]
- myoblast differentiation [IEP]
- negative regulation of apoptotic signaling pathway [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of chondrocyte differentiation [ISO]
- negative regulation of mitotic cell cycle, embryonic [ISO, ISS]
- negative regulation of neuron death [ISO]
- negative regulation of oligodendrocyte differentiation [ISO]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of protein sumoylation [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- nephron tubule formation [ISO]
- neural plate development [ISO]
- neuron migration [ISO]
- odontogenesis of dentin-containing tooth [IEP, ISO]
- oocyte development [ISO]
- organ development [ISO]
- osteoclast differentiation [ISO]
- oviduct development [ISO]
- pancreas development [ISO]
- patterning of blood vessels [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of branching involved in lung morphogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of determination of dorsal identity [ISO]
- positive regulation of endothelial cell differentiation [ISO]
- positive regulation of epithelial cell differentiation [ISO]
- positive regulation of epithelial cell proliferation involved in prostate gland development [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of fibroblast growth factor receptor signaling pathway [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [ISO, ISS]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of neuroblast proliferation [ISO, ISS]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of telomerase activity [ISO]
- positive regulation of telomere maintenance via telomerase [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- protein heterooligomerization [IPI]
- protein localization to cell surface [ISO, ISS]
- proximal/distal pattern formation [ISO]
- regulation of T cell proliferation [ISO]
- regulation of apoptotic process [ISO]
- regulation of calcium ion import [ISO, ISS]
- regulation of cell differentiation [ISO]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [ISO]
- regulation of centriole-centriole cohesion [ISO, ISS]
- regulation of centromeric sister chromatid cohesion [ISO, ISS]
- regulation of epithelial cell differentiation [ISO]
- regulation of gene expression [ISO]
- regulation of myelination [ISO]
- regulation of nephron tubule epithelial cell differentiation [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of osteoclast differentiation [ISO]
- regulation of protein localization to cell surface [ISO, ISS]
- regulation of secondary heart field cardioblast proliferation [ISO]
- regulation of smooth muscle cell proliferation [ISO, ISS]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- renal inner medulla development [ISO]
- renal outer medulla development [ISO]
- renal system development [ISO]
- renal vesicle formation [ISO]
- response to cadmium ion [IEP]
- response to cytokine [IDA]
- response to drug [ISO]
- response to estradiol [ISO, ISS]
- response to estrogen [IDA]
- response to hormone [IEP]
- response to organic cyclic compound [IEP]
- single organismal cell-cell adhesion [IDA, ISO, ISS, TAS]
- skeletal system development [ISO]
- skin development [ISO]
- smooth muscle cell differentiation [ISO]
- sympathetic ganglion development [ISO, ISS]
- synapse organization [ISO]
- synaptic transmission [ISO]
- synaptic vesicle transport [ISO]
- thymus development [ISO]
- trachea formation [ISO]
- trachea morphogenesis [ISO]
- vasculature development [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- SMAD binding [ISO]
- alpha-catenin binding [IBA, ISO]
- cadherin binding [IDA, IPI, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- euchromatin binding [ISO]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- kinase binding [ISO]
- nitric-oxide synthase binding [IPI]
- nuclear hormone receptor binding [IBA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein phosphatase binding [IBA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IBA, ISO, ISS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO, ISS]
- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- SMAD binding [ISO]
- alpha-catenin binding [IBA, ISO]
- cadherin binding [IDA, IPI, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- euchromatin binding [ISO]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- kinase binding [ISO]
- nitric-oxide synthase binding [IPI]
- nuclear hormone receptor binding [IBA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein phosphatase binding [IBA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IBA, ISO, ISS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO, ISS]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- Z disc [ISO]
- adherens junction [ISO]
- apical junction complex [ISO]
- apical part of cell [ISO]
- basolateral plasma membrane [ISO]
- beta-catenin destruction complex [ISO, ISS]
- beta-catenin-TCF7L2 complex [ISO, ISS]
- catenin complex [IBA, ISO, ISS]
- catenin-TCF7L2 complex [ISO]
- cell [ISO]
- cell cortex [ISO, ISS]
- cell junction [ISO, ISS]
- cell periphery [ISO, ISS]
- cell projection membrane [ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [ISO, ISS]
- centrosome [ISO, ISS]
- cytoplasm [ISO, ISS, TAS]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [ISO]
- focal adhesion [ISO]
- intercalated disc [ISO]
- lamellipodium [ISO]
- lateral plasma membrane [ISO]
- membrane [IDA, ISO]
- microvillus membrane [ISO]
- neuron projection [IDA]
- nuclear euchromatin [ISO]
- nuclear transcription factor complex [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- protein complex [IDA]
- protein-DNA complex [ISO, ISS]
- synapse [IDA]
- tight junction [ISO]
- transcription factor complex [ISO, ISS]
Rattus norvegicus
PREY
TUFM
Tu translation elongation factor, mitochondrial
GO Process (1)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation.
Canonical Wnt/β-catenin signaling is an essential regulator of various cellular functions throughout development and adulthood. Aberrant Wnt/β-catenin signaling also contributes to various pathologies including cancer, necessitating an understanding of cell context-dependent mechanisms regulating this pathway. Since protein-protein interactions underpin β-catenin function and localization, we sought to identify novel β-catenin interacting partners by affinity purification coupled with tandem mass spectrometry in ... [more]
EMBO Rep. Dec. 01, 2017; 19(12); [Pubmed: 30361391]
Throughput
- High Throughput
Curated By
- BioGRID