BAIT
CTNNB1
Catnb
catenin (cadherin associated protein), beta 1
GO Process (159)
GO Function (26)
GO Component (40)
Gene Ontology Biological Process
- Schwann cell proliferation [IMP]
- T cell differentiation [ISO]
- T cell differentiation in thymus [ISO]
- Wnt signaling pathway [ISO, ISS]
- adherens junction assembly [ISO, ISS]
- adherens junction organization [ISO]
- anterior/posterior axis specification [ISO]
- bone resorption [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- canonical Wnt signaling pathway [ISO, ISS]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISO]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [ISO, ISS]
- cell adhesion [ISO, ISS]
- cell differentiation [ISO]
- cell fate determination [ISO]
- cell fate specification [ISO]
- cell maturation [ISO]
- cell morphogenesis involved in differentiation [ISO]
- cell proliferation [ISO]
- cell-matrix adhesion [ISO]
- cellular process [ISO]
- cellular protein localization [ISO]
- cellular response to growth factor stimulus [ISO, ISS]
- cellular response to indole-3-methanol [ISO, ISS]
- cellular response to insulin-like growth factor stimulus [IEP, IMP]
- cellular response to mechanical stimulus [IDA]
- cellular response to organic cyclic compound [ISO]
- central nervous system vasculogenesis [ISO]
- chromatin-mediated maintenance of transcription [ISO]
- dorsal/ventral axis specification [ISO]
- dorsal/ventral pattern formation [ISO]
- ectoderm development [ISO]
- embryonic axis specification [ISO]
- embryonic digit morphogenesis [ISO]
- embryonic foregut morphogenesis [ISO]
- embryonic forelimb morphogenesis [ISO]
- embryonic heart tube development [ISO]
- embryonic hindlimb morphogenesis [ISO]
- embryonic skeletal limb joint morphogenesis [ISO]
- endoderm formation [ISO]
- endodermal cell fate commitment [ISO]
- endothelial tube morphogenesis [ISO, ISS]
- epithelial cell differentiation involved in prostate gland development [ISO]
- epithelial tube branching involved in lung morphogenesis [ISO]
- forebrain development [ISO]
- fungiform papilla formation [ISO]
- gastrulation with mouth forming second [ISO]
- genitalia morphogenesis [ISO]
- glial cell fate determination [ISO]
- hair cycle process [ISO]
- hair follicle morphogenesis [ISO]
- hair follicle placode formation [ISO]
- heart development [ISO]
- hemopoiesis [ISO]
- in utero embryonic development [ISO]
- kidney development [ISO]
- layer formation in cerebral cortex [ISO]
- lens morphogenesis in camera-type eye [ISO]
- limb development [ISO]
- liver development [IEP]
- lung cell differentiation [ISO]
- lung development [ISO]
- lung induction [ISO]
- lung-associated mesenchyme development [ISO]
- male genitalia development [ISO]
- mesenchymal cell proliferation involved in lung development [ISO]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [ISO]
- metanephros morphogenesis [ISO]
- midgut development [IEP]
- morphogenesis of embryonic epithelium [ISO]
- myoblast differentiation [IEP]
- negative regulation of apoptotic signaling pathway [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of chondrocyte differentiation [ISO]
- negative regulation of mitotic cell cycle, embryonic [ISO, ISS]
- negative regulation of neuron death [ISO]
- negative regulation of oligodendrocyte differentiation [ISO]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of protein sumoylation [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- nephron tubule formation [ISO]
- neural plate development [ISO]
- neuron migration [ISO]
- odontogenesis of dentin-containing tooth [IEP, ISO]
- oocyte development [ISO]
- organ development [ISO]
- osteoclast differentiation [ISO]
- oviduct development [ISO]
- pancreas development [ISO]
- patterning of blood vessels [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of branching involved in lung morphogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of determination of dorsal identity [ISO]
- positive regulation of endothelial cell differentiation [ISO]
- positive regulation of epithelial cell differentiation [ISO]
- positive regulation of epithelial cell proliferation involved in prostate gland development [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of fibroblast growth factor receptor signaling pathway [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [ISO, ISS]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of neuroblast proliferation [ISO, ISS]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of telomerase activity [ISO]
- positive regulation of telomere maintenance via telomerase [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- protein heterooligomerization [IPI]
- protein localization to cell surface [ISO, ISS]
- proximal/distal pattern formation [ISO]
- regulation of T cell proliferation [ISO]
- regulation of apoptotic process [ISO]
- regulation of calcium ion import [ISO, ISS]
- regulation of cell differentiation [ISO]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [ISO]
- regulation of centriole-centriole cohesion [ISO, ISS]
- regulation of centromeric sister chromatid cohesion [ISO, ISS]
- regulation of epithelial cell differentiation [ISO]
- regulation of gene expression [ISO]
- regulation of myelination [ISO]
- regulation of nephron tubule epithelial cell differentiation [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of osteoclast differentiation [ISO]
- regulation of protein localization to cell surface [ISO, ISS]
- regulation of secondary heart field cardioblast proliferation [ISO]
- regulation of smooth muscle cell proliferation [ISO, ISS]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- renal inner medulla development [ISO]
- renal outer medulla development [ISO]
- renal system development [ISO]
- renal vesicle formation [ISO]
- response to cadmium ion [IEP]
- response to cytokine [IDA]
- response to drug [ISO]
- response to estradiol [ISO, ISS]
- response to estrogen [IDA]
- response to hormone [IEP]
- response to organic cyclic compound [IEP]
- single organismal cell-cell adhesion [IDA, ISO, ISS, TAS]
- skeletal system development [ISO]
- skin development [ISO]
- smooth muscle cell differentiation [ISO]
- sympathetic ganglion development [ISO, ISS]
- synapse organization [ISO]
- synaptic transmission [ISO]
- synaptic vesicle transport [ISO]
- thymus development [ISO]
- trachea formation [ISO]
- trachea morphogenesis [ISO]
- vasculature development [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- SMAD binding [ISO]
- alpha-catenin binding [IBA, ISO]
- cadherin binding [IDA, IPI, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- euchromatin binding [ISO]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- kinase binding [ISO]
- nitric-oxide synthase binding [IPI]
- nuclear hormone receptor binding [IBA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein phosphatase binding [IBA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IBA, ISO, ISS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO, ISS]
- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- SMAD binding [ISO]
- alpha-catenin binding [IBA, ISO]
- cadherin binding [IDA, IPI, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- euchromatin binding [ISO]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- kinase binding [ISO]
- nitric-oxide synthase binding [IPI]
- nuclear hormone receptor binding [IBA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein phosphatase binding [IBA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IBA, ISO, ISS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO, ISS]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- Z disc [ISO]
- adherens junction [ISO]
- apical junction complex [ISO]
- apical part of cell [ISO]
- basolateral plasma membrane [ISO]
- beta-catenin destruction complex [ISO, ISS]
- beta-catenin-TCF7L2 complex [ISO, ISS]
- catenin complex [IBA, ISO, ISS]
- catenin-TCF7L2 complex [ISO]
- cell [ISO]
- cell cortex [ISO, ISS]
- cell junction [ISO, ISS]
- cell periphery [ISO, ISS]
- cell projection membrane [ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [ISO, ISS]
- centrosome [ISO, ISS]
- cytoplasm [ISO, ISS, TAS]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [ISO]
- focal adhesion [ISO]
- intercalated disc [ISO]
- lamellipodium [ISO]
- lateral plasma membrane [ISO]
- membrane [IDA, ISO]
- microvillus membrane [ISO]
- neuron projection [IDA]
- nuclear euchromatin [ISO]
- nuclear transcription factor complex [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- protein complex [IDA]
- protein-DNA complex [ISO, ISS]
- synapse [IDA]
- tight junction [ISO]
- transcription factor complex [ISO, ISS]
Rattus norvegicus
PREY
DAB2IP
AIP-1, DIP1/2
DAB2 interacting protein
GO Process (65)
GO Function (21)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISO, ISS]
- activation of JUN kinase activity [ISO]
- activation of MAPKKK activity [ISO, ISS]
- cell motility involved in cerebral cortex radial glia guided migration [ISO, ISS]
- cellular protein catabolic process [ISO, ISS]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to interleukin-1 [ISO, ISS]
- cellular response to lipopolysaccharide [ISO, ISS]
- cellular response to tumor necrosis factor [ISO, ISS]
- cellular response to vascular endothelial growth factor stimulus [ISO, ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- layer formation in cerebral cortex [ISO, ISS]
- negative regulation of ERK1 and ERK2 cascade [ISO, ISS]
- negative regulation of G0 to G1 transition [ISO, ISS]
- negative regulation of GTPase activity [ISO, ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of NF-kappaB transcription factor activity [ISO, ISS]
- negative regulation of Ras GTPase activity [ISO, ISS]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of angiogenesis [ISO, ISS]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [ISO]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cyclin catabolic process [ISO, ISS]
- negative regulation of endothelial cell migration [ISO, ISS]
- negative regulation of epidermal growth factor receptor signaling pathway [IDA]
- negative regulation of epithelial cell migration [ISO, ISS]
- negative regulation of epithelial cell proliferation [ISO, ISS]
- negative regulation of epithelial to mesenchymal transition [ISO, ISS]
- negative regulation of fibroblast proliferation [ISO, ISS]
- negative regulation of phosphatidylinositol 3-kinase activity [ISO, ISS]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO, ISS]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of protein serine/threonine kinase activity [ISO, ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- negative regulation of vascular endothelial growth factor signaling pathway [ISO, ISS]
- neuron projection morphogenesis [ISO, ISS]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of MAPK cascade [ISO, ISS]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of apoptotic signaling pathway [ISO, ISS]
- positive regulation of cell cycle arrest [ISO, ISS]
- positive regulation of dendrite development [ISO, ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of neuron migration [ISO, ISS]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of proteasomal protein catabolic process [ISO, ISS]
- positive regulation of protein catabolic process [ISO, ISS]
- positive regulation of protein serine/threonine kinase activity [ISO, ISS]
- positive regulation of synapse maturation [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- regulation of ARF GTPase activity [ISO, ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- regulation of p38MAPK cascade [ISO, ISS]
- regulation of protein complex assembly [ISO, ISS]
- tube formation [ISO, ISS]
- vascular endothelial growth factor receptor-2 signaling pathway [ISO, ISS]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IDA]
- SH3 domain binding [ISO, ISS]
- Toll-like receptor 4 binding [ISO]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO, ISS]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO, ISS]
- phosphatidylinositol-3-phosphate binding [ISO, ISS]
- phosphatidylinositol-4-phosphate binding [ISO, ISS]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO, ISS]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IDA]
- SH3 domain binding [ISO, ISS]
- Toll-like receptor 4 binding [ISO]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO, ISS]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO, ISS]
- phosphatidylinositol-3-phosphate binding [ISO, ISS]
- phosphatidylinositol-4-phosphate binding [ISO, ISS]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO, ISS]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- axon [ISO, ISS]
- cerebellar mossy fiber [ISO, ISS]
- climbing fiber [ISO, ISS]
- cytoplasm [IBA, ISO, ISS]
- endocytic vesicle [ISO, ISS]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [ISO, ISS]
- neuronal cell body membrane [ISO, ISS]
- parallel fiber [ISO, ISS]
- plasma membrane [ISO, ISS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation.
Canonical Wnt/β-catenin signaling is an essential regulator of various cellular functions throughout development and adulthood. Aberrant Wnt/β-catenin signaling also contributes to various pathologies including cancer, necessitating an understanding of cell context-dependent mechanisms regulating this pathway. Since protein-protein interactions underpin β-catenin function and localization, we sought to identify novel β-catenin interacting partners by affinity purification coupled with tandem mass spectrometry in ... [more]
EMBO Rep. Dec. 01, 2017; 19(12); [Pubmed: 30361391]
Throughput
- High Throughput
Curated By
- BioGRID