BAIT
TENM1
ODZ1, ODZ3, TEN-M1, TNM, TNM1, RP5-1052M9.2
teneurin transmembrane protein 1
GO Process (9)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- immune response [TAS]
- negative regulation of cell proliferation [TAS]
- nervous system development [TAS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of intracellular protein transport [ISS]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- regulation of transcription from RNA polymerase III promoter [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APBB1
FE65, MGC:9072, RIR
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
GO Process (10)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- axonogenesis [NAS]
- cell cycle arrest [ISS]
- cellular response to DNA damage stimulus [IDA]
- histone H4 acetylation [ISS]
- negative regulation of cell growth [ISS]
- negative regulation of thymidylate synthase biosynthetic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [ISS]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The intracellular domain of teneurin-1 induces the activity of microphthalmia-associated transcription factor (MITF) by binding to transcriptional repressor HINT1.
Teneurins are large type II transmembrane proteins that are necessary for the normal development of the CNS. Although many studies highlight the significance of teneurins, especially during development, there is only limited information known about the molecular mechanisms of function. Previous studies have shown that the N-terminal intracellular domain (ICD) of teneurins can be cleaved at the membrane and subsequently ... [more]
J. Biol. Chem. Mar. 27, 2015; 290(13);8154-65 [Pubmed: 25648896]
Throughput
- Low Throughput
Curated By
- BioGRID