BAIT
TENM1
ODZ1, ODZ3, TEN-M1, TNM, TNM1, RP5-1052M9.2
teneurin transmembrane protein 1
GO Process (9)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- immune response [TAS]
- negative regulation of cell proliferation [TAS]
- nervous system development [TAS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of intracellular protein transport [ISS]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- regulation of transcription from RNA polymerase III promoter [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PICALM
CALM, CLTH, LAP
phosphatidylinositol binding clathrin assembly protein
GO Process (22)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- cargo loading into vesicle [IMP]
- cell proliferation [IMP]
- clathrin coat assembly [IMP]
- clathrin-mediated endocytosis [IMP]
- endosomal transport [IMP]
- iron ion homeostasis [IMP]
- iron ion import into cell [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [ISS]
- negative regulation of receptor-mediated endocytosis [IDA]
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISS]
- positive regulation of beta-amyloid formation [IMP]
- positive regulation of neuron death [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- protein complex assembly [TAS]
- receptor internalization [IMP]
- receptor-mediated endocytosis [IDA, ISS]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [IMP]
- regulation of endocytosis [IMP]
- regulation of protein localization [IDA]
- synaptic vesicle maturation [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [IDA]
- clathrin coat of coated pit [IDA]
- coated pit [IDA, ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [IDA]
- neurofibrillary tangle [IMP]
- neuronal cell body [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISS]
- postsynaptic membrane [ISS]
- presynaptic membrane [ISS]
- vesicle [ISS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The intracellular domain of teneurin-1 induces the activity of microphthalmia-associated transcription factor (MITF) by binding to transcriptional repressor HINT1.
Teneurins are large type II transmembrane proteins that are necessary for the normal development of the CNS. Although many studies highlight the significance of teneurins, especially during development, there is only limited information known about the molecular mechanisms of function. Previous studies have shown that the N-terminal intracellular domain (ICD) of teneurins can be cleaved at the membrane and subsequently ... [more]
J. Biol. Chem. Mar. 27, 2015; 290(13);8154-65 [Pubmed: 25648896]
Throughput
- Low Throughput
Curated By
- BioGRID