TRPC7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FKBP1A
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- T cell proliferation [ISO]
- amyloid fibril formation [ISO]
- chaperone-mediated protein folding [IBA]
- cytokine-mediated signaling pathway [ISO]
- extracellular fibril organization [ISO]
- heart morphogenesis [ISO]
- heart trabecula formation [ISO]
- muscle contraction [ISO]
- negative regulation of protein phosphatase type 2B activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [IBA, ISO]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein peptidyl-prolyl isomerization [IBA, ISO]
- regulation of activin receptor signaling pathway [ISO]
- regulation of amyloid precursor protein catabolic process [ISO]
- regulation of immune response [ISO]
- regulation of protein localization [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- release of sequestered calcium ion into cytosol [ISO]
- response to caffeine [ISO]
- response to iron ion [IEP]
- ventricular cardiac muscle tissue morphogenesis [ISO]
Gene Ontology Molecular Function- FK506 binding [IDA, ISO]
- Hsp70 protein binding [IPI]
- SMAD binding [ISO]
- activin binding [ISO]
- calcium channel inhibitor activity [IBA, ISO]
- drug binding [ISO]
- enzyme binding [IPI]
- ion channel binding [ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- signal transducer activity [ISO]
- transforming growth factor beta receptor binding [IDA]
- type I transforming growth factor beta receptor binding [IDA]
- FK506 binding [IDA, ISO]
- Hsp70 protein binding [IPI]
- SMAD binding [ISO]
- activin binding [ISO]
- calcium channel inhibitor activity [IBA, ISO]
- drug binding [ISO]
- enzyme binding [IPI]
- ion channel binding [ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- signal transducer activity [ISO]
- transforming growth factor beta receptor binding [IDA]
- type I transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of immunophilins with mammalian TRPC channels.
Drosophila photoreceptor channels TRP and TRPL are held in a large signalplex by the scaffolding protein, INAD. Immunophilin FKBP59, another member of the signalplex, binds to both INAD and TRPL. Mutation P702Q or P709Q in the highly conserved TRPL sequence (701)LPPPFNVLP(709), eliminates TRPL interaction with FKBP59. The first leucylprolyl (LP) dipeptide in this region is conserved in mammalian TRPC channel ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID