BAIT
TEX101
CT131, GTPR867, NYD-SP8, PRO1884, SGRG, SPATA44, TES101RP, UNQ867/PRO1884
testis expressed 101
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
CLU
APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, AAG4
clusterin
GO Process (35)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell morphogenesis [IDA]
- central nervous system myelin maintenance [IMP]
- chaperone-mediated protein complex assembly [IDA]
- chaperone-mediated protein folding [IDA]
- complement activation [TAS]
- intrinsic apoptotic signaling pathway [IDA]
- lipid metabolic process [NAS]
- microglial cell activation [IDA]
- microglial cell proliferation [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of protein homooligomerization [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of beta-amyloid formation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of neurofibrillary tangle assembly [IMP]
- positive regulation of neuron death [IDA, IMP]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of tau-protein kinase activity [IMP]
- positive regulation of tumor necrosis factor production [IDA]
- protein import [IDA]
- protein stabilization [IDA]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA, IMP]
- regulation of neuronal signal transduction [IMP]
- release of cytochrome c from mitochondria [IC]
- response to misfolded protein [IDA]
- response to virus [IEP]
- reverse cholesterol transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical dendrite [IDA]
- blood microparticle [IDA]
- cytoplasm [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- mitochondrion [IDA]
- neurofibrillary tangle [IDA]
- perinuclear region of cytoplasm [IDA]
- platelet alpha granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.
TEX101 is a testis-specific protein expressed exclusively in male germ cells and is a validated biomarker of male infertility. Studies in mice suggest that TEX101 is a cell-surface chaperone which regulates, through protein-protein interactions, the maturation of proteins involved in spermatozoa transit and oocyte binding. Male TEX101-null mice are sterile. Here, we identified by co-immunoprecipitation-mass spectrometry the interactome of human ... [more]
Mol. Cell Proteomics Dec. 01, 2017; 17(12);2480-2495 [Pubmed: 30097533]
Throughput
- High Throughput
Curated By
- BioGRID