BAIT
BARD1
BRCA1 associated RING domain 1
GO Process (11)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- cell cycle arrest [NAS]
- cellular response to DNA damage stimulus [NAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of mRNA 3'-end processing [NAS]
- negative regulation of protein export from nucleus [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of protein catabolic process [NAS]
- protein K6-linked ubiquitination [IDA]
- protein ubiquitination [NAS]
- regulation of phosphorylation [IMP]
- tissue homeostasis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TUBG1
CDCBM4, GCP-1, TUBG, TUBGCP1
tubulin, gamma 1
GO Process (4)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number.
BRCA1 functions as a tumor suppressor in DNA repair and centrosome regulation. Previously, Obg-like ATPase 1 (OLA1) was shown to interact with BARD1, a heterodimer partner of BRCA1. OLA1 binds to BRCA1, BARD1, and ?-tubulin and functions in centrosome regulation. This study determined that overexpression of wild-type OLA1 (OLA1-WT) caused centrosome amplification due to centriole overduplication in mammary tissue-derived cells. ... [more]
Mol. Cancer Res. Dec. 01, 2017; 16(10);1499-1511 [Pubmed: 29858377]
Throughput
- Low Throughput
Curated By
- BioGRID