BAIT
PSAP
AI037048, SGP-1
prosaposin
GO Process (6)
GO Function (0)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
ACTR2
4921510D23Rik, AA409782, Arp2, D6Ertd746e, RP23-19L22.1
ARP2 actin-related protein 2
GO Process (10)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- Arp2/3 complex-mediated actin nucleation [ISO]
- actin cytoskeleton organization [IMP]
- asymmetric cell division [IGI]
- cilium assembly [ISO]
- cytoplasmic transport [IMP]
- establishment or maintenance of cell polarity [IGI]
- meiotic cell cycle [IGI]
- meiotic chromosome movement towards spindle pole [IGI]
- meiotic cytokinesis [IGI]
- spindle localization [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes is still not clear. Here we report a novel pathway for lysosomal delivery of PGRN. We found that prosaposin (PSAP) ... [more]
J. Cell Biol. Sep. 14, 2015; 210(6);991-1002 [Pubmed: 26370502]
Throughput
- High Throughput
Additional Notes
- assayed using SILAC IP (stable isotope labeling by amino acids in cell culture-based quantitative immunoprecipitation)
Curated By
- BioGRID