BAIT
PSAP
AI037048, SGP-1
prosaposin
GO Process (6)
GO Function (0)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA2
70kDa, HSP70.2, HSP70A2, Hsp70-2
heat shock protein 2
GO Process (8)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- male meiosis [IMP]
- male meiosis I [IMP]
- negative regulation of inclusion body assembly [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- positive regulation of protein phosphorylation [IMP]
- protein refolding [ISO]
- spermatid development [IMP]
- synaptonemal complex disassembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes is still not clear. Here we report a novel pathway for lysosomal delivery of PGRN. We found that prosaposin (PSAP) ... [more]
J. Cell Biol. Sep. 14, 2015; 210(6);991-1002 [Pubmed: 26370502]
Throughput
- High Throughput
Additional Notes
- assayed using SILAC IP (stable isotope labeling by amino acids in cell culture-based quantitative immunoprecipitation)
Curated By
- BioGRID