BAIT
HAP1
HAP1-A, HAP1-B
huntingtin-associated protein 1
GO Process (21)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- anterograde axon cargo transport [IMP, ISO]
- cellular response to growth factor stimulus [IEP]
- cerebellum development [ISO]
- early endosome to late endosome transport [TAS]
- hypothalamus cell differentiation [ISO]
- negative regulation of beta-amyloid formation [IMP]
- neuron projection development [IDA]
- neurotrophin TRK receptor signaling pathway [ISO, ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [IMP]
- positive regulation of inclusion body assembly [IDA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- positive regulation of neurogenesis [ISO]
- positive regulation of neuron projection development [IDA]
- positive regulation of neurotrophin production [IDA, IMP]
- positive regulation of nonmotile primary cilium assembly [ISO, ISS]
- positive regulation of synaptic transmission, GABAergic [IDA, IMP]
- protein localization [ISO]
- regulation of exocytosis [ISO, ISS]
- regulation of organelle transport along microtubule [ISO, ISS]
- retrograde axon cargo transport [IMP]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSPA1L
Hsp70-3
heat shock protein 1-like
GO Process (2)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.
Huntingtin-associated protein 1 (HAP1) was initially identified as a binding partner of huntingtin, mutations in which underlie Huntington's disease. Subcellular localization and protein interaction data indicate that HAP1 may be important in vesicle trafficking, cell signalling and receptor internalization. In this study, a proteomics approach was used for the identification of novel HAP1-interacting partners to attempt to shed light on ... [more]
Cell. Signal. Dec. 01, 2016; 35();176-187 [Pubmed: 28259758]
Throughput
- Low Throughput
Curated By
- BioGRID