BAIT
HAP1
HAP1-A, HAP1-B
huntingtin-associated protein 1
GO Process (21)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- anterograde axon cargo transport [IMP, ISO]
- cellular response to growth factor stimulus [IEP]
- cerebellum development [ISO]
- early endosome to late endosome transport [TAS]
- hypothalamus cell differentiation [ISO]
- negative regulation of beta-amyloid formation [IMP]
- neuron projection development [IDA]
- neurotrophin TRK receptor signaling pathway [ISO, ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [IMP]
- positive regulation of inclusion body assembly [IDA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- positive regulation of neurogenesis [ISO]
- positive regulation of neuron projection development [IDA]
- positive regulation of neurotrophin production [IDA, IMP]
- positive regulation of nonmotile primary cilium assembly [ISO, ISS]
- positive regulation of synaptic transmission, GABAergic [IDA, IMP]
- protein localization [ISO]
- regulation of exocytosis [ISO, ISS]
- regulation of organelle transport along microtubule [ISO, ISS]
- retrograde axon cargo transport [IMP]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ANXA1
Anx1, p35
annexin A1
GO Process (39)
GO Function (12)
GO Component (14)
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- DNA duplex unwinding [IMP]
- DNA rewinding [IMP]
- DNA strand renaturation [IMP]
- alpha-beta T cell differentiation [ISO]
- arachidonic acid secretion [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to glucocorticoid stimulus [IDA, ISO]
- cellular response to hydrogen peroxide [IMP]
- endocrine pancreas development [IEP]
- estrous cycle phase [IEP]
- gliogenesis [IEP]
- hepatocyte differentiation [IEP]
- insulin secretion [IDA]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [IDA]
- negative regulation of protein secretion [IMP]
- neutrophil clearance [ISO]
- neutrophil homeostasis [ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of neutrophil apoptotic process [ISO]
- positive regulation of prostaglandin biosynthetic process [IMP]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [IMP]
- prostate gland development [IEP]
- regulation of cell proliferation [ISO]
- response to X-ray [IEP]
- response to corticosteroid [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucocorticoid [IEP]
- response to hormone [IEP]
- response to interleukin-1 [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- signal transduction [ISO]
Gene Ontology Molecular Function- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
- cell surface [ISO]
- cornified envelope [ISO]
- cytoplasm [IDA, ISO]
- endosome [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- mast cell granule [IDA]
- mitochondrial membrane [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- sarcolemma [ISO]
- vesicle [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.
Huntingtin-associated protein 1 (HAP1) was initially identified as a binding partner of huntingtin, mutations in which underlie Huntington's disease. Subcellular localization and protein interaction data indicate that HAP1 may be important in vesicle trafficking, cell signalling and receptor internalization. In this study, a proteomics approach was used for the identification of novel HAP1-interacting partners to attempt to shed light on ... [more]
Cell. Signal. Dec. 01, 2016; 35();176-187 [Pubmed: 28259758]
Throughput
- Low Throughput
Curated By
- BioGRID