BAIT

HAP1

HAP1-A, HAP1-B
huntingtin-associated protein 1
GO Process (21)
GO Function (6)
GO Component (13)
Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.

Mackenzie KD, Lim Y, Duffield MD, Chataway T, Zhou XF, Keating DJ

Huntingtin-associated protein 1 (HAP1) was initially identified as a binding partner of huntingtin, mutations in which underlie Huntington's disease. Subcellular localization and protein interaction data indicate that HAP1 may be important in vesicle trafficking, cell signalling and receptor internalization. In this study, a proteomics approach was used for the identification of novel HAP1-interacting partners to attempt to shed light on ... [more]

Cell. Signal. Dec. 01, 2016; 35();176-187 [Pubmed: 28259758]

Throughput

  • Low Throughput

Curated By

  • BioGRID