BAIT
HAP1
HAP1-A, HAP1-B
huntingtin-associated protein 1
GO Process (21)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- anterograde axon cargo transport [IMP, ISO]
- cellular response to growth factor stimulus [IEP]
- cerebellum development [ISO]
- early endosome to late endosome transport [TAS]
- hypothalamus cell differentiation [ISO]
- negative regulation of beta-amyloid formation [IMP]
- neuron projection development [IDA]
- neurotrophin TRK receptor signaling pathway [ISO, ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [IMP]
- positive regulation of inclusion body assembly [IDA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- positive regulation of neurogenesis [ISO]
- positive regulation of neuron projection development [IDA]
- positive regulation of neurotrophin production [IDA, IMP]
- positive regulation of nonmotile primary cilium assembly [ISO, ISS]
- positive regulation of synaptic transmission, GABAergic [IDA, IMP]
- protein localization [ISO]
- regulation of exocytosis [ISO, ISS]
- regulation of organelle transport along microtubule [ISO, ISS]
- retrograde axon cargo transport [IMP]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ARG1
arginase 1
GO Process (35)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- aging [IEP]
- arginine catabolic process to ornithine [IDA]
- arginine metabolic process [IDA]
- cellular response to dexamethasone stimulus [IEP]
- cellular response to glucagon stimulus [IEP]
- cellular response to hydrogen peroxide [IEP]
- cellular response to interleukin-4 [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to transforming growth factor beta stimulus [IEP]
- collagen biosynthetic process [IMP]
- female pregnancy [IEP]
- liver development [IEP]
- lung development [IEP]
- mammary gland involution [IEP]
- maternal process involved in female pregnancy [IEP]
- positive regulation of endothelial cell proliferation [IDA]
- protein homotrimerization [IDA]
- regulation of L-arginine import [IDA]
- response to amine [IEP]
- response to amino acid [IEP]
- response to axon injury [IEP]
- response to cadmium ion [IEP]
- response to drug [IEP]
- response to herbicide [IEP]
- response to lipopolysaccharide [IEP]
- response to manganese ion [IEP]
- response to methylmercury [IEP]
- response to peptide hormone [IEP]
- response to selenium ion [IEP]
- response to steroid hormone [IEP]
- response to vitamin A [IEP]
- response to vitamin E [IEP]
- response to wounding [IEP]
- response to zinc ion [IEP]
- urea cycle [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.
Huntingtin-associated protein 1 (HAP1) was initially identified as a binding partner of huntingtin, mutations in which underlie Huntington's disease. Subcellular localization and protein interaction data indicate that HAP1 may be important in vesicle trafficking, cell signalling and receptor internalization. In this study, a proteomics approach was used for the identification of novel HAP1-interacting partners to attempt to shed light on ... [more]
Cell. Signal. Dec. 01, 2016; 35();176-187 [Pubmed: 28259758]
Throughput
- Low Throughput
Curated By
- BioGRID