SYT1
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [TAS]
- detection of calcium ion [IC, IDA]
- fast, calcium ion-dependent exocytosis of neurotransmitter [ISS]
- neurotransmitter secretion [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of synaptic transmission [ISS]
- positive regulation of vesicle fusion [IDA]
- regulation of calcium ion-dependent exocytosis [IMP]
- regulation of regulated secretory pathway [IMP]
- regulation of synaptic transmission, glutamatergic [ISS]
- response to calcium ion [IDA]
- synaptic vesicle exocytosis [ISO, TAS]
- vesicle docking [IDA]
Gene Ontology Molecular Function- SNARE binding [IDA, IPI]
- calcium ion binding [IDA, IMP, ISO, TAS]
- calcium-dependent phospholipid binding [IDA]
- calcium-dependent protein binding [IDA, ISO]
- calmodulin binding [IDA]
- clathrin binding [IDA]
- identical protein binding [IPI]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylserine binding [IDA]
- phospholipid binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- syntaxin binding [IDA]
- syntaxin-1 binding [IDA]
- SNARE binding [IDA, IPI]
- calcium ion binding [IDA, IMP, ISO, TAS]
- calcium-dependent phospholipid binding [IDA]
- calcium-dependent protein binding [IDA, ISO]
- calmodulin binding [IDA]
- clathrin binding [IDA]
- identical protein binding [IPI]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylserine binding [IDA]
- phospholipid binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- syntaxin binding [IDA]
- syntaxin-1 binding [IDA]
Gene Ontology Cellular Component
- SNARE complex [IDA]
- cell [ISO]
- cytoplasm [IDA, TAS]
- dense core granule [IDA]
- excitatory synapse [IDA]
- intracellular organelle [IDA]
- neuron projection [ISO]
- plasma membrane [IDA]
- presynaptic membrane [ISO]
- secretory granule [IDA, ISO]
- synaptic vesicle [IDA, ISO]
- synaptic vesicle membrane [ISO, TAS]
- terminal bouton [IDA]
SET
Gene Ontology Biological Process
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.
Synaptotagmins represent a family of neuronal proteins thought to function in membrane traffic. The best characterized synaptotagmin, synaptotagmin I, is essential for fast Ca2+-dependent synaptic vesicle exocytosis, indicating a role in the Ca2+ triggering of membrane fusion. Synaptotagmins contain two C2 domains, the C2A and C2B domains, which bind Ca2+ and may mediate their functions by binding to specific targets. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID