BAIT
SYT1
P65
synaptotagmin I
GO Process (13)
GO Function (15)
GO Component (13)
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [TAS]
- detection of calcium ion [IC, IDA]
- fast, calcium ion-dependent exocytosis of neurotransmitter [ISS]
- neurotransmitter secretion [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of synaptic transmission [ISS]
- positive regulation of vesicle fusion [IDA]
- regulation of calcium ion-dependent exocytosis [IMP]
- regulation of regulated secretory pathway [IMP]
- regulation of synaptic transmission, glutamatergic [ISS]
- response to calcium ion [IDA]
- synaptic vesicle exocytosis [ISO, TAS]
- vesicle docking [IDA]
Gene Ontology Molecular Function- SNARE binding [IDA, IPI]
- calcium ion binding [IDA, IMP, ISO, TAS]
- calcium-dependent phospholipid binding [IDA]
- calcium-dependent protein binding [IDA, ISO]
- calmodulin binding [IDA]
- clathrin binding [IDA]
- identical protein binding [IPI]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylserine binding [IDA]
- phospholipid binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- syntaxin binding [IDA]
- syntaxin-1 binding [IDA]
- SNARE binding [IDA, IPI]
- calcium ion binding [IDA, IMP, ISO, TAS]
- calcium-dependent phospholipid binding [IDA]
- calcium-dependent protein binding [IDA, ISO]
- calmodulin binding [IDA]
- clathrin binding [IDA]
- identical protein binding [IPI]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylserine binding [IDA]
- phospholipid binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- syntaxin binding [IDA]
- syntaxin-1 binding [IDA]
Gene Ontology Cellular Component
- SNARE complex [IDA]
- cell [ISO]
- cytoplasm [IDA, TAS]
- dense core granule [IDA]
- excitatory synapse [IDA]
- intracellular organelle [IDA]
- neuron projection [ISO]
- plasma membrane [IDA]
- presynaptic membrane [ISO]
- secretory granule [IDA, ISO]
- synaptic vesicle [IDA, ISO]
- synaptic vesicle membrane [ISO, TAS]
- terminal bouton [IDA]
Rattus norvegicus
PREY
RPA2
replication protein A2
GO Process (9)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- DNA replication [IC, ISO, ISS]
- base-excision repair [ISO, ISS, NAS]
- double-strand break repair via homologous recombination [ISO, ISS]
- mismatch repair [ISO, ISS]
- mitotic G1 DNA damage checkpoint [ISO]
- nucleotide-excision repair [ISO, ISS]
- regulation of DNA damage checkpoint [ISO, ISS]
- regulation of double-strand break repair via homologous recombination [ISO, ISS]
- telomere maintenance [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.
Synaptotagmins represent a family of neuronal proteins thought to function in membrane traffic. The best characterized synaptotagmin, synaptotagmin I, is essential for fast Ca2+-dependent synaptic vesicle exocytosis, indicating a role in the Ca2+ triggering of membrane fusion. Synaptotagmins contain two C2 domains, the C2A and C2B domains, which bind Ca2+ and may mediate their functions by binding to specific targets. ... [more]
Biochemistry Mar. 21, 2000; 39(11);2940-9 [Pubmed: 10715114]
Throughput
- Low Throughput
Curated By
- BioGRID