VCP
Gene Ontology Biological Process
- ATP catabolic process [IDA, IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [ISO, ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- aggresome assembly [ISO]
- cellular response to DNA damage stimulus [ISO, ISS]
- double-strand break repair [ISO, ISS]
- positive regulation of Lys63-specific deubiquitinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP, ISO]
- positive regulation of protein K63-linked deubiquitination [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein N-linked glycosylation via asparagine [ISO, ISS]
- protein hexamerization [IDA]
- protein homooligomerization [IDA]
- protein ubiquitination [ISO, ISS]
- retrograde protein transport, ER to cytosol [ISO]
- translesion synthesis [ISO, ISS]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipid particle [ISO]
- myelin sheath [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- proteasome complex [ISO]
- protein complex [ISO]
- site of double-strand break [ISO, ISS]
SYT1
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [TAS]
- detection of calcium ion [IC, IDA]
- fast, calcium ion-dependent exocytosis of neurotransmitter [ISS]
- neurotransmitter secretion [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of synaptic transmission [ISS]
- positive regulation of vesicle fusion [IDA]
- regulation of calcium ion-dependent exocytosis [IMP]
- regulation of regulated secretory pathway [IMP]
- regulation of synaptic transmission, glutamatergic [ISS]
- response to calcium ion [IDA]
- synaptic vesicle exocytosis [ISO, TAS]
- vesicle docking [IDA]
Gene Ontology Molecular Function- SNARE binding [IDA, IPI]
- calcium ion binding [IDA, IMP, ISO, TAS]
- calcium-dependent phospholipid binding [IDA]
- calcium-dependent protein binding [IDA, ISO]
- calmodulin binding [IDA]
- clathrin binding [IDA]
- identical protein binding [IPI]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylserine binding [IDA]
- phospholipid binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- syntaxin binding [IDA]
- syntaxin-1 binding [IDA]
- SNARE binding [IDA, IPI]
- calcium ion binding [IDA, IMP, ISO, TAS]
- calcium-dependent phospholipid binding [IDA]
- calcium-dependent protein binding [IDA, ISO]
- calmodulin binding [IDA]
- clathrin binding [IDA]
- identical protein binding [IPI]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylserine binding [IDA]
- phospholipid binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- syntaxin binding [IDA]
- syntaxin-1 binding [IDA]
Gene Ontology Cellular Component
- SNARE complex [IDA]
- cell [ISO]
- cytoplasm [IDA, TAS]
- dense core granule [IDA]
- excitatory synapse [IDA]
- intracellular organelle [IDA]
- neuron projection [ISO]
- plasma membrane [IDA]
- presynaptic membrane [ISO]
- secretory granule [IDA, ISO]
- synaptic vesicle [IDA, ISO]
- synaptic vesicle membrane [ISO, TAS]
- terminal bouton [IDA]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.
Synaptotagmins represent a family of neuronal proteins thought to function in membrane traffic. The best characterized synaptotagmin, synaptotagmin I, is essential for fast Ca2+-dependent synaptic vesicle exocytosis, indicating a role in the Ca2+ triggering of membrane fusion. Synaptotagmins contain two C2 domains, the C2A and C2B domains, which bind Ca2+ and may mediate their functions by binding to specific targets. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VCP SYT1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SYT1 VCP | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID