An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.

Shulla A, Heald-Sargent T, Subramanya G, Zhao J, Perlman S, Gallagher T

Spike (S) proteins, the defining projections of the enveloped coronaviruses (CoVs), mediate cell entry by connecting viruses to plasma membrane receptors and by catalyzing subsequent virus-cell membrane fusions. The latter membrane fusion requires an S protein conformational flexibility that is facilitated by proteolytic cleavages. We hypothesized that the most relevant cellular proteases in this process are those closely linked to ... [more]

J. Virol. Jan. 01, 2011; 85(2);873-82 [Pubmed: 21068237]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TMPRSS11D

Gene Ontology Biological Process

Gene Ontology Molecular Function

peptidase activity [TAS]

Gene Ontology Cellular Component

ACE2