BAIT
AGO2
EIF2C2, Q10
argonaute RISC catalytic component 2
GO Process (18)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Notch signaling pathway [TAS]
- RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- gene silencing by RNA [ISS]
- innate immune response [TAS]
- mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translational initiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]
- pre-miRNA processing [IDA]
- translation [NAS]
- translational initiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GDNF
ATF1, ATF2, HFB1-GDNF, HSCR3
glial cell derived neurotrophic factor
GO Process (23)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- adult locomotory behavior [TAS]
- axon guidance [TAS]
- branching involved in ureteric bud morphogenesis [ISS]
- enteric nervous system development [ISS]
- mRNA stabilization [IDA]
- metanephros development [ISS]
- negative regulation of apoptotic process [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of neuron apoptotic process [IDA]
- nervous system development [TAS]
- neural crest cell migration [IDA]
- neuron projection development [IDA]
- peristalsis [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA]
- positive regulation of dopamine secretion [TAS]
- positive regulation of monooxygenase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of ureteric bud formation [IDA]
- postganglionic parasympathetic nervous system development [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IDA]
- regulation of morphogenesis of a branching structure [ISS]
- signal transduction [TAS]
- sympathetic nervous system development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2.
Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in the DMPK gene, leading to mutated-transcript RNA-toxicity. MicroRNAs (miRNAs) are short non-coding RNAs that, after maturation, are loaded onto the RISC effector complex that destabilizes target mRNAs and represses their translation. In DM1 muscle biopsies not only the expression, but also ... [more]
Cell Death Dis Dec. 28, 2017; 9(7);729 [Pubmed: 29955039]
Throughput
- High Throughput
Curated By
- BioGRID