GRM1
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO, ISS]
- G-protein coupled receptor signaling pathway [ISO, ISS]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [ISO]
- calcium-mediated signaling [IDA]
- cellular response to electrical stimulus [ISO]
- dimeric G-protein coupled receptor signaling pathway [ISO, ISS]
- locomotory behavior [ISO]
- membrane depolarization [TAS]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO, ISS, TAS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA]
- regulation of MAPK cascade [ISO]
- regulation of glutamate secretion [TAS]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic transmission, glutamatergic [IDA]
- sensory perception of pain [IEP, ISO]
- synaptic transmission [IEP]
- synaptic transmission, GABAergic [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTK2B
Gene Ontology Biological Process
- MAPK cascade [IMP]
- actin filament organization [IMP]
- activation of Janus kinase activity [IMP, ISO]
- activation of Rac GTPase activity [IMP]
- angiogenesis [IMP]
- blood vessel endothelial cell migration [IMP]
- bone resorption [ISO, ISS]
- cell adhesion [IMP]
- cell differentiation [IEP]
- cell surface receptor signaling pathway [ISO, ISS]
- cellular defense response [IMP]
- cellular response to retinoic acid [ISO]
- chemokine-mediated signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IMP]
- focal adhesion assembly [IMP]
- glial cell proliferation [IEP]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IMP]
- long-term synaptic potentiation [IMP]
- marginal zone B cell differentiation [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of bone mineralization [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of ossification [IMP]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [IMP]
- oocyte maturation [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, IMP]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of B cell chemotaxis [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of actin filament polymerization [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [IEP, ISO]
- positive regulation of cell-matrix adhesion [ISO, ISS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- positive regulation of translation [IMP]
- protein phosphorylation [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of actin cytoskeleton reorganization [ISO, ISS]
- regulation of cGMP biosynthetic process [ISO]
- regulation of cGMP-mediated signaling [ISO]
- regulation of calcium-mediated signaling [ISO]
- regulation of cell adhesion [IBA, ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of establishment of cell polarity [ISO, ISS]
- regulation of inositol trisphosphate biosynthetic process [ISO, ISS]
- regulation of macrophage chemotaxis [ISO, ISS]
- regulation of nitric oxide biosynthetic process [ISO]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of release of sequestered calcium ion into cytosol [ISO, ISS]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hormone [IEP]
- response to hydrogen peroxide [IPI]
- response to hypoxia [IEP]
- response to immobilization stress [IEP]
- response to lithium ion [IEP]
- response to mechanical stimulus [IEP]
- response to organonitrogen compound [IEP]
- response to osmotic stress [IEP]
- response to reactive oxygen species [IEP]
- sprouting angiogenesis [ISO, ISS]
- stress fiber assembly [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, IMP]
- apical dendrite [IDA]
- axon [IDA]
- cell body [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- dendrite [IDA]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- growth cone [IDA]
- lamellipodium [ISO, ISS]
- membrane raft [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- postsynaptic density [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.
Group I metabotropic glutamate receptors (mGluRs) are coupled via Galphaq/11 to the activation of phospholipase Cbeta, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. This results in the release of Ca2+ from intracellular stores and the activation of protein kinase C. The activation of Group I mGluRs also results in ERK1/2 phosphorylation. We show here, that the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID