SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA5
Gene Ontology Biological Process
- ER overload response [ISO]
- activation of signaling protein activity involved in unfolded protein response [ISO]
- cellular response to antibiotic [IEP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [ISO]
- cerebellar Purkinje cell layer development [ISO]
- cerebellum structural organization [ISO]
- maintenance of protein localization in endoplasmic reticulum [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of protein ubiquitination [ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
- response to endoplasmic reticulum stress [IDA]
- substantia nigra development [ISO]
- toxin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [ISO]
- endoplasmic reticulum [IDA, ISO, TAS]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [ISO]
- endoplasmic reticulum membrane [ISO]
- endoplasmic reticulum-Golgi intermediate compartment [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [IDA, ISO]
- midbody [ISO]
- mitochondrion [IDA]
- myelin sheath [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- smooth endoplasmic reticulum [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Throughput
- High Throughput
Curated By
- BioGRID