SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ANXA1
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- DNA duplex unwinding [IMP]
- DNA rewinding [IMP]
- DNA strand renaturation [IMP]
- alpha-beta T cell differentiation [ISO]
- arachidonic acid secretion [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to glucocorticoid stimulus [IDA, ISO]
- cellular response to hydrogen peroxide [IMP]
- endocrine pancreas development [IEP]
- estrous cycle phase [IEP]
- gliogenesis [IEP]
- hepatocyte differentiation [IEP]
- insulin secretion [IDA]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [IDA]
- negative regulation of protein secretion [IMP]
- neutrophil clearance [ISO]
- neutrophil homeostasis [ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of neutrophil apoptotic process [ISO]
- positive regulation of prostaglandin biosynthetic process [IMP]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [IMP]
- prostate gland development [IEP]
- regulation of cell proliferation [ISO]
- response to X-ray [IEP]
- response to corticosteroid [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucocorticoid [IEP]
- response to hormone [IEP]
- response to interleukin-1 [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- signal transduction [ISO]
Gene Ontology Molecular Function- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
- cell surface [ISO]
- cornified envelope [ISO]
- cytoplasm [IDA, ISO]
- endosome [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- mast cell granule [IDA]
- mitochondrial membrane [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- sarcolemma [ISO]
- vesicle [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Throughput
- High Throughput
Curated By
- BioGRID