SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ANXA2
Gene Ontology Biological Process
- angiogenesis [ISO]
- body fluid secretion [IMP]
- collagen fibril organization [ISO]
- fibrinolysis [ISO]
- membrane budding [ISO]
- membrane raft assembly [ISO]
- negative regulation of catalytic activity [ISO]
- osteoclast development [ISO]
- positive regulation of binding [ISO]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of vesicle fusion [ISO]
- protein heterotetramerization [ISO]
- protein targeting to plasma membrane [IMP]
- regulation of fibrinolysis [TAS]
Gene Ontology Molecular Function- Rab GTPase binding [IPI]
- S100 protein binding [ISO]
- actin filament binding [TAS]
- calcium ion binding [TAS]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA, ISO]
- phospholipase A2 inhibitor activity [ISO]
- poly(A) RNA binding [ISO]
- Rab GTPase binding [IPI]
- S100 protein binding [ISO]
- actin filament binding [TAS]
- calcium ion binding [TAS]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [IDA, ISO]
- phospholipase A2 inhibitor activity [ISO]
- poly(A) RNA binding [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [ISO]
- cell cortex [IDA]
- cell surface [ISO]
- cytoplasm [IDA, ISO]
- early endosome [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [ISO]
- late endosome membrane [ISO]
- lipid particle [ISO]
- lysosomal membrane [ISO]
- macropinosome [IDA]
- membrane [ISO]
- membrane raft [ISO]
- midbody [ISO]
- myelin sheath adaxonal region [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- ruffle [IDA]
- sarcolemma [ISO]
- vesicle [IDA, ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Throughput
- High Throughput
Curated By
- BioGRID