BAIT
SOST
CDD, SOST1, VBCH, UNQ2976/PRO7455/PRO7476
sclerostin
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APOE
APOEA
apolipoprotein E
GO Process (89)
GO Function (17)
GO Component (28)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- N-methyl-D-aspartate receptor clustering [ISO]
- aging [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO]
- artery morphogenesis [ISO]
- axon regeneration [ISO]
- cGMP-mediated signaling [ISO]
- cardiovascular system development [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to cholesterol [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to interleukin-1 [IEP]
- cholesterol catabolic process [ISO]
- cholesterol efflux [ISO]
- cholesterol homeostasis [ISO]
- cholesterol metabolic process [ISO]
- chylomicron remnant clearance [ISO]
- fatty acid homeostasis [ISO]
- high-density lipoprotein particle assembly [ISO]
- high-density lipoprotein particle clearance [ISO]
- high-density lipoprotein particle remodeling [ISO]
- lipid homeostasis [ISO]
- lipid metabolic process [ISO]
- lipid transport [IDA]
- lipoprotein biosynthetic process [ISO]
- lipoprotein catabolic process [ISO]
- lipoprotein metabolic process [IDA, ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle remodeling [ISO]
- maintenance of location in cell [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of blood coagulation [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of cholesterol efflux [ISO]
- negative regulation of dendritic spine development [ISO]
- negative regulation of dendritic spine maintenance [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of lipid biosynthetic process [ISO]
- negative regulation of lipid transport across blood brain barrier [ISO]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [ISO]
- negative regulation of phospholipid efflux [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of postsynaptic membrane organization [ISO]
- negative regulation of presynaptic membrane organization [ISO]
- neuron projection regeneration [TAS]
- nitric oxide mediated signal transduction [ISO]
- oligodendrocyte differentiation [IEP]
- peripheral nervous system axon regeneration [IEP]
- phospholipid efflux [ISO]
- positive regulation of axon extension [IDA]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of cGMP biosynthetic process [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of dendritic spine maintenance [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of lipid transport across blood brain barrier [ISO]
- positive regulation of low-density lipoprotein particle receptor catabolic process [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of phospholipid efflux [ISO]
- positive regulation of postsynaptic membrane organization [ISO]
- positive regulation of presynaptic membrane organization [ISO]
- protein import [ISO]
- protein localization [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of beta-amyloid clearance [ISO]
- regulation of gene expression [ISO]
- regulation of neuron death [ISO]
- regulation of tau-protein kinase activity [ISO]
- response to dietary excess [ISO]
- response to ethanol [IEP]
- response to insulin [IEP]
- response to oxidative stress [ISO]
- response to retinoic acid [IEP]
- reverse cholesterol transport [ISO]
- triglyceride metabolic process [ISO]
- vasodilation [ISO]
- very-low-density lipoprotein particle clearance [ISO]
- very-low-density lipoprotein particle remodeling [ISO]
Gene Ontology Molecular Function- antioxidant activity [ISO]
- beta-amyloid binding [IDA, ISO, ISS]
- cholesterol transporter activity [ISO]
- heparin binding [ISO]
- hydroxyapatite binding [IDA]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [IDA, ISO]
- lipoprotein particle binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [ISO]
- phospholipid binding [IDA, ISO]
- protein homodimerization activity [ISO]
- receptor binding [IPI]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [ISO]
- antioxidant activity [ISO]
- beta-amyloid binding [IDA, ISO, ISS]
- cholesterol transporter activity [ISO]
- heparin binding [ISO]
- hydroxyapatite binding [IDA]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [IDA, ISO]
- lipoprotein particle binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [ISO]
- phospholipid binding [IDA, ISO]
- protein homodimerization activity [ISO]
- receptor binding [IPI]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- blood microparticle [ISO]
- cell [ISO]
- cell surface [IDA]
- chylomicron [ISO]
- cytoplasm [IDA]
- dendrite [IDA]
- discoidal high-density lipoprotein particle [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of external side of plasma membrane [IDA]
- high-density lipoprotein particle [ISO]
- intermediate-density lipoprotein particle [ISO]
- late endosome [IDA]
- low-density lipoprotein particle [ISO]
- lysosome [IDA]
- membrane [ISO]
- microtubule [IDA]
- neuronal cell body [IDA]
- nuclear envelope [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Biochem. Biophys. Res. Commun. Jan. 13, 2012; 417(2);830-5 [Pubmed: 22206666]
Throughput
- High Throughput
Curated By
- BioGRID