BAIT
SOST
CDD, SOST1, VBCH, UNQ2976/PRO7455/PRO7476
sclerostin
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APOE
APOEA
apolipoprotein E
GO Process (89)
GO Function (17)
GO Component (28)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- N-methyl-D-aspartate receptor clustering [ISO]
- aging [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO]
- artery morphogenesis [ISO]
- axon regeneration [ISO]
- cGMP-mediated signaling [ISO]
- cardiovascular system development [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to cholesterol [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to interleukin-1 [IEP]
- cholesterol catabolic process [ISO]
- cholesterol efflux [ISO]
- cholesterol homeostasis [ISO]
- cholesterol metabolic process [ISO]
- chylomicron remnant clearance [ISO]
- fatty acid homeostasis [ISO]
- high-density lipoprotein particle assembly [ISO]
- high-density lipoprotein particle clearance [ISO]
- high-density lipoprotein particle remodeling [ISO]
- lipid homeostasis [ISO]
- lipid metabolic process [ISO]
- lipid transport [IDA]
- lipoprotein biosynthetic process [ISO]
- lipoprotein catabolic process [ISO]
- lipoprotein metabolic process [IDA, ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle remodeling [ISO]
- maintenance of location in cell [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of blood coagulation [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of cholesterol efflux [ISO]
- negative regulation of dendritic spine development [ISO]
- negative regulation of dendritic spine maintenance [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of lipid biosynthetic process [ISO]
- negative regulation of lipid transport across blood brain barrier [ISO]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [ISO]
- negative regulation of phospholipid efflux [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of postsynaptic membrane organization [ISO]
- negative regulation of presynaptic membrane organization [ISO]
- neuron projection regeneration [TAS]
- nitric oxide mediated signal transduction [ISO]
- oligodendrocyte differentiation [IEP]
- peripheral nervous system axon regeneration [IEP]
- phospholipid efflux [ISO]
- positive regulation of axon extension [IDA]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of cGMP biosynthetic process [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of dendritic spine maintenance [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of lipid transport across blood brain barrier [ISO]
- positive regulation of low-density lipoprotein particle receptor catabolic process [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of phospholipid efflux [ISO]
- positive regulation of postsynaptic membrane organization [ISO]
- positive regulation of presynaptic membrane organization [ISO]
- protein import [ISO]
- protein localization [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of beta-amyloid clearance [ISO]
- regulation of gene expression [ISO]
- regulation of neuron death [ISO]
- regulation of tau-protein kinase activity [ISO]
- response to dietary excess [ISO]
- response to ethanol [IEP]
- response to insulin [IEP]
- response to oxidative stress [ISO]
- response to retinoic acid [IEP]
- reverse cholesterol transport [ISO]
- triglyceride metabolic process [ISO]
- vasodilation [ISO]
- very-low-density lipoprotein particle clearance [ISO]
- very-low-density lipoprotein particle remodeling [ISO]
Gene Ontology Molecular Function- antioxidant activity [ISO]
- beta-amyloid binding [IDA, ISO, ISS]
- cholesterol transporter activity [ISO]
- heparin binding [ISO]
- hydroxyapatite binding [IDA]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [IDA, ISO]
- lipoprotein particle binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [ISO]
- phospholipid binding [IDA, ISO]
- protein homodimerization activity [ISO]
- receptor binding [IPI]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [ISO]
- antioxidant activity [ISO]
- beta-amyloid binding [IDA, ISO, ISS]
- cholesterol transporter activity [ISO]
- heparin binding [ISO]
- hydroxyapatite binding [IDA]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [IDA, ISO]
- lipoprotein particle binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [ISO]
- phospholipid binding [IDA, ISO]
- protein homodimerization activity [ISO]
- receptor binding [IPI]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- blood microparticle [ISO]
- cell [ISO]
- cell surface [IDA]
- chylomicron [ISO]
- cytoplasm [IDA]
- dendrite [IDA]
- discoidal high-density lipoprotein particle [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of external side of plasma membrane [IDA]
- high-density lipoprotein particle [ISO]
- intermediate-density lipoprotein particle [ISO]
- late endosome [IDA]
- low-density lipoprotein particle [ISO]
- lysosome [IDA]
- membrane [ISO]
- microtubule [IDA]
- neuronal cell body [IDA]
- nuclear envelope [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Biochem. Biophys. Res. Commun. Jan. 13, 2012; 417(2);830-5 [Pubmed: 22206666]
Throughput
- High Throughput
Curated By
- BioGRID