SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CAR2
Gene Ontology Biological Process
- angiotensin-activated signaling pathway [ISO, ISS]
- carbon dioxide transport [ISO]
- cellular response to fluid shear stress [IEP]
- kidney development [IEP]
- morphogenesis of an epithelium [ISO]
- odontogenesis of dentin-containing tooth [IEP]
- osteoclast differentiation [TAS]
- positive regulation of bone resorption [IMP]
- positive regulation of cellular pH reduction [IMP, ISO]
- positive regulation of dipeptide transmembrane transport [ISO, ISS]
- positive regulation of osteoclast differentiation [IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- regulation of anion transport [ISO, ISS]
- regulation of bone resorption [TAS]
- regulation of cellular pH [TAS]
- regulation of chloride transport [ISO]
- regulation of intracellular pH [ISO, ISS]
- response to estrogen [IEP]
- response to organic substance [IEP]
- response to pH [IEP]
- response to steroid hormone [IEP]
- response to zinc ion [IEP]
- secretion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Throughput
- High Throughput
Curated By
- BioGRID