BAIT
SOST
CDD, SOST1, VBCH, UNQ2976/PRO7455/PRO7476
sclerostin
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CAR2
Ca2
carbonic anhydrase 2
GO Process (23)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- angiotensin-activated signaling pathway [ISO, ISS]
- carbon dioxide transport [ISO]
- cellular response to fluid shear stress [IEP]
- kidney development [IEP]
- morphogenesis of an epithelium [ISO]
- odontogenesis of dentin-containing tooth [IEP]
- osteoclast differentiation [TAS]
- positive regulation of bone resorption [IMP]
- positive regulation of cellular pH reduction [IMP, ISO]
- positive regulation of dipeptide transmembrane transport [ISO, ISS]
- positive regulation of osteoclast differentiation [IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- regulation of anion transport [ISO, ISS]
- regulation of bone resorption [TAS]
- regulation of cellular pH [TAS]
- regulation of chloride transport [ISO]
- regulation of intracellular pH [ISO, ISS]
- response to estrogen [IEP]
- response to organic substance [IEP]
- response to pH [IEP]
- response to steroid hormone [IEP]
- response to zinc ion [IEP]
- secretion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Biochem. Biophys. Res. Commun. Jan. 13, 2012; 417(2);830-5 [Pubmed: 22206666]
Throughput
- High Throughput
Curated By
- BioGRID