SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CAT
Gene Ontology Biological Process
- UV protection [ISO]
- aerobic respiration [ISO]
- aging [IEP]
- cellular response to growth factor stimulus [IEP]
- cholesterol metabolic process [ISO]
- hemoglobin metabolic process [ISO]
- hydrogen peroxide catabolic process [IDA, IMP, ISO]
- kidney development [IMP]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- osteoblast differentiation [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- protein homotetramerization [ISO]
- protein tetramerization [ISO]
- response to L-ascorbic acid [IEP]
- response to UV [IEP]
- response to activity [IEP]
- response to cadmium ion [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to fatty acid [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IMP]
- response to inactivity [IEP]
- response to insulin [IEP]
- response to lead ion [IEP]
- response to light intensity [IEP]
- response to oxidative stress [IDA, ISO]
- response to ozone [IEP]
- response to phenylpropanoid [IEP]
- response to radiation [IEP]
- response to reactive oxygen species [IMP, ISO]
- response to toxic substance [IEP]
- response to vitamin A [IEP]
- response to vitamin E [IEP]
- triglyceride metabolic process [ISO]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cytosol [IDA]
- endoplasmic reticulum [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- lysosome [IDA]
- membrane [ISO]
- mitochondrial intermembrane space [IDA]
- mitochondrion [ISO]
- peroxisomal membrane [ISO]
- peroxisome [IDA, ISO]
- plasma membrane [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Throughput
- High Throughput
Curated By
- BioGRID