SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SERPINE2
Gene Ontology Biological Process
- blood coagulation [ISO]
- cerebellar granular layer morphogenesis [ISO]
- dense core granule biogenesis [IDA]
- detection of mechanical stimulus involved in sensory perception [ISO]
- embryo implantation [IEP]
- innervation [ISO]
- long-term synaptic potentiation [ISO]
- mating plug formation [ISO]
- negative regulation of blood coagulation [IDA, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endopeptidase activity [IBA, ISO]
- negative regulation of peptidase activity [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of plasminogen activation [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of platelet aggregation [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of proteolysis [IDA, ISO]
- negative regulation of smoothened signaling pathway [ISO]
- negative regulation of sodium ion transport [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of neuron projection development [IDA]
- regulation of synaptic transmission, glutamatergic [ISO]
- regulation of timing of cell differentiation [ISO]
- response to radiation [IEP]
- response to wounding [ISO]
- secretion by cell [ISO]
- secretory granule organization [IDA, ISO]
- seminal vesicle epithelium development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Throughput
- High Throughput
Curated By
- BioGRID