BAIT
SOST
CDD, SOST1, VBCH, UNQ2976/PRO7455/PRO7476
sclerostin
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPA8
Hsc70
heat shock 70kDa protein 8
GO Process (10)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- chaperone mediated protein folding requiring cofactor [IDA, ISO]
- chaperone-mediated protein folding [IDA]
- clathrin coat disassembly [ISO]
- negative regulation of fibril organization [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- positive regulation of mRNA splicing, via spliceosome [ISO]
- protein folding [ISO]
- protein refolding [ISO]
- regulation of cell cycle [ISO]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA, ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IMP, ISO]
- ADP binding [IDA]
- ATP binding [IDA, ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IMP, ISO]
Gene Ontology Cellular Component
- Prp19 complex [ISO, ISS]
- blood microparticle [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [IDA, ISO]
- focal adhesion [ISO]
- intracellular [ISO]
- membrane [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO, ISS]
- protein complex [IDA]
- ribonucleoprotein complex [ISO, ISS]
- synaptic vesicle [IDA]
- terminal bouton [IDA]
- ubiquitin ligase complex [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Biochem. Biophys. Res. Commun. Jan. 13, 2012; 417(2);830-5 [Pubmed: 22206666]
Throughput
- High Throughput
Curated By
- BioGRID