BAIT
SOST
CDD, SOST1, VBCH, UNQ2976/PRO7455/PRO7476
sclerostin
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NRP1
Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISO]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [ISO]
- angiogenesis [ISO]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- artery morphogenesis [ISO]
- axon extension involved in axon guidance [ISO]
- axon guidance [IMP, ISO]
- axonal fasciculation [ISO]
- axonogenesis involved in innervation [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [ISO]
- coronary artery morphogenesis [ISO]
- dendrite development [ISO]
- dichotomous subdivision of terminal units involved in salivary gland branching [ISO]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [ISO]
- heart development [ISO]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of axon extension involved in axon guidance [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- nerve development [ISO]
- nervous system development [NAS]
- neural crest cell migration involved in autonomic nervous system development [ISO]
- neuron development [ISO]
- neuron migration [ISO]
- patterning of blood vessels [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of axon extension involved in axon guidance [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of retinal ganglion cell axon guidance [ISO]
- protein localization to early endosome [ISO]
- regulation of axon extension involved in axon guidance [ISO]
- regulation of retinal ganglion cell axon guidance [ISO]
- renal artery morphogenesis [ISO]
- response to wounding [IEP]
- retina vasculature morphogenesis in camera-type eye [ISO]
- retinal ganglion cell axon guidance [ISO]
- semaphorin-plexin signaling pathway [ISO]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISO]
- sprouting angiogenesis [ISO]
- sympathetic ganglion development [ISO]
- sympathetic nervous system development [ISO]
- sympathetic neuron projection extension [ISO]
- sympathetic neuron projection guidance [ISO]
- toxin transport [ISO]
- trigeminal nerve morphogenesis [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Biochem. Biophys. Res. Commun. Jan. 13, 2012; 417(2);830-5 [Pubmed: 22206666]
Throughput
- High Throughput
Curated By
- BioGRID