SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of ossification [NAS]
- negative regulation of protein complex assembly [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- response to mechanical stimulus [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
THY1
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- angiogenesis [ISO, ISS]
- cytoskeleton organization [IDA]
- focal adhesion assembly [IDA]
- mast cell activation [NAS]
- negative regulation of T cell receptor signaling pathway [ISO, ISS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of fibroblast proliferation [NAS]
- negative regulation of protein kinase activity [IDA]
- positive regulation of GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [NAS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- retinal cone cell development [ISO, ISS]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- anchored component of external side of plasma membrane [ISO]
- anchored component of plasma membrane [IDA]
- apical plasma membrane [ISO]
- cell surface [IDA, TAS]
- cytosol [IDA]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [ISO, ISS]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [IDA]
- membrane raft [ISO]
- myelin sheath [ISO]
- plasma membrane [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The sclerostin-bone protein interactome.
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP amylose column. The columns were extensively washed with low ... [more]
Throughput
- High Throughput
Curated By
- BioGRID