BAIT

NCAM1

CD56, MSK39, NCAM

neural cell adhesion molecule 1

Synthetic Protein Interaction Project

GO Process (4)

GO Function (1)

GO Component (6)

Gene Ontology Biological Process

axon guidance [TAS]

cytokine-mediated signaling pathway [TAS]

extracellular matrix organization [TAS]

interferon-gamma-mediated signaling pathway [TAS]

Gene Ontology Molecular Function

identical protein binding [IPI]

Gene Ontology Cellular Component

Golgi membrane [TAS]

cell surface [IDA]

external side of plasma membrane [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PRNP

AA960666, AI325101, CD230, PrP, PrP, PrPC, PrPSc, Prn-i, Prn-p, Sinc, prP27-30, prP33-35C, RP23-401J24.1

prion protein

GO Process (19)

GO Function (7)

GO Component (10)

Gene Ontology Biological Process

cellular copper ion homeostasis [TAS]

cellular response to copper ion [ISO]

cellular response to drug [IDA]

learning or memory [ISO]

negative regulation of T cell receptor signaling pathway [IMP]

negative regulation of activated T cell proliferation [IMP]

negative regulation of apoptotic process [IGI, ISO]

negative regulation of calcineurin-NFAT signaling cascade [IMP]

negative regulation of interferon-gamma production [IMP]

negative regulation of interleukin-17 production [IMP]

negative regulation of interleukin-2 production [IMP]

negative regulation of protein phosphorylation [IMP]

negative regulation of sequence-specific DNA binding transcription factor activity [IMP]

nucleobase-containing compound metabolic process [TAS]

regulation of potassium ion transmembrane transport [IGI]

regulation of protein localization [IMP]

response to cadmium ion [ISO]

response to copper ion [ISO]

response to oxidative stress [IDA]

Gene Ontology Molecular Function

ATP-dependent protein binding [ISO]
chaperone binding [ISO]
copper ion binding [IDA, ISO]
identical protein binding [IPI, ISO]
microtubule binding [ISO]
protein binding [IPI]
tubulin binding [ISO]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

cell surface [IDA, ISO]

cytoplasm [ISO]

endoplasmic reticulum [IDA]

extracellular vesicular exosome [ISO]

membrane [IDA, ISO]

membrane raft [IDA, ISO, TAS]

mitochondrial outer membrane [ISO]

plasma membrane [IDA, ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.

Slapsak U, Salzano G, Amin L, Abskharon RN, Ilc G, Zupancic B, Biljan I, Plavec J, Giachin G, Legname G

The cellular form of the prion protein (PrPC) is a highly conserved glycoprotein mostly expressed in the central and peripheral nervous systems by different cell types in mammals. A misfolded, pathogenic isoform, denoted as prion, is related to a class of neurodegenerative diseases known as transmissible spongiform encephalopathy. PrPC function has not been unequivocally clarified, and it is rather defined ... [more]

J. Biol. Chem. Oct. 14, 2016; 291(42);21857-21868 [Pubmed: 27535221]

Throughput

Low Throughput

Curated By

BioGRID