ADORA2A
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adenosine receptor signaling pathway [IDA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IMP, ISO]
- astrocyte activation [IMP]
- eating behavior [IMP, ISO]
- locomotory behavior [IMP, ISO]
- membrane depolarization [IMP]
- negative regulation of alpha-beta T cell activation [ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of inflammatory response [ISO]
- negative regulation of locomotion [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of vascular permeability [IMP]
- neuron projection morphogenesis [IDA, IMP]
- positive regulation of acetylcholine secretion, neurotransmission [IMP]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of circadian sleep/wake cycle, sleep [IDA]
- positive regulation of glutamate secretion [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of renal sodium excretion [IDA, IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [IDA]
- positive regulation of urine volume [IMP]
- prepulse inhibition [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- regulation of calcium ion transport [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of mitochondrial membrane potential [IDA]
- regulation of norepinephrine secretion [IMP]
- regulation of synaptic plasticity [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to alkaloid [IMP]
- response to amphetamine [ISO]
- response to caffeine [IDA]
- response to drug [IEP]
- synaptic transmission, cholinergic [IMP]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [IDA]
- vasodilation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- asymmetric synapse [IDA]
- axolemma [IDA]
- axon [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- integral component of plasma membrane [ISO]
- intermediate filament [IDA]
- membrane [IDA, ISO]
- neuronal cell body [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA]
HRH3
Gene Ontology Biological Process
- brain development [IEP]
- cognition [IMP]
- drinking behavior [IMP]
- eating behavior [IMP]
- learning [IMP]
- memory [IMP]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [IMP]
- negative regulation of gamma-aminobutyric acid secretion [IMP]
- negative regulation of glutamate secretion [IMP]
- negative regulation of serotonin secretion [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- regulation of norepinephrine secretion [IMP]
- response to organic cyclic compound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum.
In the striatum, histamine H3 receptors (H3Rs) are co-expressed with adenosine A2A receptors (A2ARs) in the cortico-striatal glutamatergic afferents and the GABAergic medium-sized spiny neurons that originate the indirect pathway of the basal ganglia. This location allows H3Rs and A2ARs to regulate the striatal GABAergic and glutamatergic transmission. However, whether these receptors can physically interact has not yet been assessed. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HRH3 ADORA2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID