GRIA4
Gene Ontology Biological Process
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, IMP, ISO, TAS]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- regulation of synapse structure or activity [TAS]
- regulation of synaptic transmission [IMP]
- response to fungicide [IEP]
- synaptic transmission [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- dendrite [IDA, IMP]
- ionotropic glutamate receptor complex [TAS]
- kainate selective glutamate receptor complex [IDA]
- neuronal cell body [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA]
- synapse [IMP, ISO]
- terminal bouton [IDA]
- vesicle [ISO]
GRIA1
Gene Ontology Biological Process
- cellular response to amine stimulus [IEP]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to peptide hormone stimulus [IEP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- long term synaptic depression [ISO]
- long-term memory [IMP, ISO]
- neuronal action potential [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of synaptic transmission [IMP]
- receptor internalization [IDA, ISO]
- regulation of receptor recycling [IMP]
- regulation of synaptic plasticity [IMP, NAS]
- regulation of synaptic transmission [IDA]
- response to arsenic-containing substance [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to estradiol [IEP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to toxic substance [IMP]
- spinal cord development [IEP]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [NAS]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- axonal spine [ISO]
- cell surface [IDA, ISO]
- cytosol [IDA]
- dendrite [ISO, ISS]
- dendrite membrane [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [IDA]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [ISO, TAS]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- protein complex [IDA]
- recycling endosome [ISO]
- synapse [IDA, IMP, ISO]
- synaptic vesicle [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of an interactome for long-form AMPA receptor subunits.
Glutamate receptors of the AMPA-type mediate fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity. The binding of these receptors to a variety of proteins is known to regulate their targeting to the synapse and consequently to modulate synaptic strength, as well as to modify receptor characteristics. In this study, a proteomic screening ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIA1 GRIA4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIA4 GRIA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID