BAIT
GRIA4
GluA4, GluR-D, GluR4
glutamate receptor, ionotropic, AMPA 4
GO Process (7)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, IMP, ISO, TAS]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- regulation of synapse structure or activity [TAS]
- regulation of synaptic transmission [IMP]
- response to fungicide [IEP]
- synaptic transmission [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- dendrite [IDA, IMP]
- ionotropic glutamate receptor complex [TAS]
- kainate selective glutamate receptor complex [IDA]
- neuronal cell body [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA]
- synapse [IMP, ISO]
- terminal bouton [IDA]
- vesicle [ISO]
Rattus norvegicus
PREY
SHANK2
CortBP1, ProSAP1, Spank-3
SH3 and multiple ankyrin repeat domains 2
GO Process (11)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- adult behavior [ISO, ISS]
- brain development [IEP]
- exploration behavior [ISO, ISS]
- learning [ISO, ISS]
- long term synaptic depression [ISO, ISS]
- long-term synaptic potentiation [ISO, ISS]
- memory [ISO, ISS]
- response to nutrient [IEP]
- social behavior [ISO, ISS]
- synapse assembly [ISO, ISS]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- brush border membrane [IDA]
- ciliary membrane [IDA]
- dendritic spine [ISO, ISS]
- growth cone [IDA]
- ionotropic glutamate receptor complex [ISO, ISS]
- neurofilament [ISO, ISS]
- neuron projection [ISO, ISS]
- neuronal cell body [IDA]
- photoreceptor inner segment [ISO, ISS]
- photoreceptor outer segment [ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic density [IDA]
- postsynaptic membrane [ISO, ISS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of an interactome for long-form AMPA receptor subunits.
Glutamate receptors of the AMPA-type mediate fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity. The binding of these receptors to a variety of proteins is known to regulate their targeting to the synapse and consequently to modulate synaptic strength, as well as to modify receptor characteristics. In this study, a proteomic screening ... [more]
J. Proteome Res. Apr. 05, 2010; 9(4);1670-82 [Pubmed: 20131911]
Throughput
- High Throughput
Curated By
- BioGRID