NACA
Gene Ontology Biological Process
- cardiac ventricle development [ISS]
- heart trabecula morphogenesis [ISS]
- negative regulation of striated muscle cell apoptotic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter involved in heart development [ISS]
- positive regulation of cell proliferation involved in heart morphogenesis [ISS]
- positive regulation of skeletal muscle tissue growth [ISS]
- positive regulation of transcription from RNA polymerase II promoter involved in heart development [ISS]
- regulation of skeletal muscle fiber development [ISS]
- skeletal muscle tissue regeneration [ISS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP1R12A
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- centrosome organization [IMP]
- mitotic cell cycle [TAS]
- mitotic nuclear division [IMP]
- negative regulation of catalytic activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein dephosphorylation [IMP]
- regulation of cell adhesion [IDA]
- regulation of myosin-light-chain-phosphatase activity [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.
The transcriptional cofactor nascent polypeptide-associated complex and co-regulator ? (NACA) regulates osteoblast maturation and activity. NACA functions, at least in part, by binding to Jun proto-oncogene, AP-1 transcription factor subunit (cJUN) and potentiating the transactivation of AP-1 targets such as osteocalcin (Bglap) and matrix metallopeptidase 9 (Mmp9). NACA activity is modulated by phosphorylation carried out by several kinases, but a ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NACA PPP1R12A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID