BAIT
AES
AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5
amino-terminal enhancer of split
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- multicellular organismal development [TAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of protein binding [IDA]
- negative regulation of response to cytokine stimulus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [TAS]
- positive regulation of anoikis [IMP]
- response to interleukin-1 [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
SH3GL3
CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13
SH3-domain GRB2-like 3
GO Process (2)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID