BAIT

LRRK2

AURA17, DARDARIN, PARK8, RIPK7, ROCO2
leucine-rich repeat kinase 2
GO Process (61)
GO Function (21)
GO Component (23)

Gene Ontology Biological Process

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

Lee JH, Han JH, Kim H, Park SM, Joe EH, Jou I

Accumulating evidence indicates that endoplasmic reticulum (ER) stress is a common feature of Parkinson's disease (PD) and further suggests that several PD-related genes are responsible for ER dysfunction. However, the underlying mechanisms are largely unknown. Here, we defined the mechanism by which LRRK2-G2019S (LRRK2-GS), a pathogenic mutation in the PD-associated gene LRRK2, accelerates ER stress and cell death. Treatment of ... [more]

Acta Neuropathol Commun Dec. 02, 2018; 7(1);68 [Pubmed: 31046837]

Throughput

  • High Throughput

Curated By

  • BioGRID