BAIT
KMT2E
HDCMC04P, MLL5, NKp44L
lysine (K)-specific methyltransferase 2E
GO Process (9)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA methylation [ISS]
- cellular response to retinoic acid [IDA]
- erythrocyte differentiation [ISS]
- histone H3-K4 methylation [IDA]
- neutrophil activation [ISS]
- neutrophil mediated immunity [ISS]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- retinoic acid receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID