BAIT
AP2B1
ADTB2, AP105B, AP2-BETA, CLAPB1
adaptor-related protein complex 2, beta 1 subunit
GO Process (9)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
COL3A1
EDS4A
collagen, type III, alpha 1
GO Process (20)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- axon guidance [TAS]
- cell-matrix adhesion [IDA]
- cerebral cortex development [ISS]
- collagen catabolic process [TAS]
- collagen fibril organization [IMP, NAS]
- extracellular fibril organization [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- heart development [IMP]
- integrin-mediated signaling pathway [IMP]
- negative regulation of immune response [IMP]
- negative regulation of neuron migration [ISS]
- peptide cross-linking [IDA]
- platelet activation [NAS]
- positive regulation of Rho protein signal transduction [ISS]
- response to cytokine [IDA]
- response to radiation [IDA]
- skin development [IMP]
- transforming growth factor beta receptor signaling pathway [IDA]
- wound healing [IDA, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID