BAIT
IL6
BSF2, HGF, HSF, IFNB2, IL-6
interleukin 6
GO Process (51)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- T-helper 17 cell lineage commitment [ISS]
- acute-phase response [TAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to lipopolysaccharide [IMP]
- cytokine-mediated signaling pathway [IDA]
- defense response to Gram-negative bacterium [IEP]
- defense response to Gram-positive bacterium [IEP]
- defense response to virus [IDA]
- endocrine pancreas development [ISS]
- glucagon secretion [ISS]
- hepatic immune response [IDA, TAS]
- humoral immune response [IC]
- inflammatory response [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- monocyte chemotaxis [IC]
- negative regulation of apoptotic process [IDA]
- negative regulation of chemokine biosynthetic process [ISS]
- negative regulation of collagen biosynthetic process [IDA]
- negative regulation of fat cell differentiation [NAS]
- negative regulation of lipid storage [NAS]
- neuron projection development [IMP]
- neutrophil apoptotic process [IDA]
- neutrophil mediated immunity [IC]
- platelet activation [TAS]
- positive regulation of B cell activation [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of STAT protein import into nucleus [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of acute inflammatory response [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of chemokine production [IDA, IMP]
- positive regulation of immunoglobulin secretion [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of leukocyte chemotaxis [IC]
- positive regulation of osteoblast differentiation [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of translation [IDA]
- positive regulation of type B pancreatic cell apoptotic process [TAS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of angiogenesis [IC]
- regulation of vascular endothelial growth factor production [IDA]
- response to glucocorticoid [IDA]
- response to peptidoglycan [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SH3GL2
CNSA2, EEN-B1, SH3D2A, SH3P4
SH3-domain GRB2-like 2
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- central nervous system development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- post-Golgi vesicle-mediated transport [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID