BAIT
KCNH2
ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2
GO Process (19)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cellular response to drug [IDA]
- membrane depolarization during action potential [IDA]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IMP]
- negative regulation of potassium ion export [IDA]
- negative regulation of potassium ion transmembrane transport [IDA]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion homeostasis [IDA]
- potassium ion transmembrane transport [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of heart rate by hormone [TAS]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transport [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- synaptic transmission [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- delayed rectifier potassium channel activity [IDA]
- identical protein binding [IPI]
- inward rectifier potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- delayed rectifier potassium channel activity [IDA]
- identical protein binding [IPI]
- inward rectifier potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
NDUFS6
CI-13kA, CI-13kD-A, CI13KDA
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID