ANKS1A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAB2IP
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISS]
- activation of JUN kinase activity [IDA]
- activation of MAPKKK activity [IDA]
- cell motility involved in cerebral cortex radial glia guided migration [ISS]
- cellular protein catabolic process [IDA]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISS]
- endothelial cell apoptotic process [TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- layer formation in cerebral cortex [ISS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of G0 to G1 transition [IDA]
- negative regulation of GTPase activity [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [IDA, IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of Ras GTPase activity [IMP]
- negative regulation of Ras protein signal transduction [IBA, IC]
- negative regulation of angiogenesis [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of catenin import into nucleus [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin catabolic process [IDA]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISS]
- negative regulation of epithelial cell migration [IMP, TAS]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial to mesenchymal transition [IDA, IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of phosphatidylinositol 3-kinase activity [IDA]
- negative regulation of phosphatidylinositol 3-kinase signaling [IDA]
- negative regulation of protein phosphorylation [IMP, ISS]
- negative regulation of protein serine/threonine kinase activity [IDA, IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- negative regulation of vascular endothelial growth factor signaling pathway [ISS]
- neuron projection morphogenesis [ISS]
- positive regulation of JNK cascade [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of apoptotic process [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of dendrite development [ISS]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of proteasomal protein catabolic process [IMP]
- positive regulation of protein catabolic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, IMP]
- positive regulation of synapse maturation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of ARF GTPase activity [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of p38MAPK cascade [ISS]
- regulation of protein complex assembly [IDA]
- transformed cell apoptotic process [TAS]
- tube formation [IMP]
- vascular endothelial growth factor receptor-2 signaling pathway [ISS]
Gene Ontology Molecular Function- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
Gene Ontology Cellular Component
- axon [ISS]
- cerebellar mossy fiber [ISS]
- climbing fiber [ISS]
- cytoplasm [IDA]
- endocytic vesicle [IDA]
- extracellular vesicular exosome [IDA]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [ISS]
- neuronal cell body membrane [ISS]
- parallel fiber [ISS]
- plasma membrane [IDA]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DAB2IP ANKS1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2218281 | |
DAB2IP ANKS1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3107473 |
Curated By
- BioGRID