BAIT
PLCE1
NPHS3, PLCE, PPLC, RP11-76P2.1
phospholipase C, epsilon 1
GO Process (22)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPK activity [IDA]
- calcium-mediated signaling [NAS, TAS]
- cell proliferation [NAS]
- cytoskeleton organization [NAS]
- diacylglycerol biosynthetic process [TAS]
- epidermal growth factor receptor signaling pathway [NAS]
- glomerulus development [IMP]
- heart development [TAS]
- inositol phosphate metabolic process [TAS]
- inositol phosphate-mediated signaling [TAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phospholipid metabolic process [IC]
- positive regulation of GTPase activity [TAS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [NAS]
- regulation of G-protein coupled receptor protein signaling pathway [IDA]
- regulation of Ras protein signal transduction [IDA]
- regulation of cell growth [TAS]
- regulation of protein kinase activity [IDA]
- regulation of smooth muscle contraction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
NRAS
ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, RP5-1000E10.2
neuroblastoma RAS viral (v-ras) oncogene homolog
GO Process (13)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID