BAIT
PTOV1
ACID2, PTOV-1, PP642
prostate tumor overexpressed 1
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
DMTN
DMT, EPB49
dematin actin binding protein
GO Process (28)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- actin filament bundle assembly [IDA, TAS]
- actin filament reorganization [ISS]
- calcium-mediated signaling using extracellular calcium source [ISS]
- calcium-mediated signaling using intracellular calcium source [ISS]
- cellular response to cAMP [IDA]
- cellular response to calcium ion [ISS]
- cytoskeleton organization [TAS]
- erythrocyte development [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of protein targeting to membrane [ISS]
- negative regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of blood coagulation [ISS]
- positive regulation of fibroblast migration [ISS]
- positive regulation of integrin-mediated signaling pathway [ISS]
- positive regulation of platelet aggregation [ISS]
- positive regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of wound healing [ISS]
- protein complex assembly [IDA, ISS]
- protein secretion by platelet [ISS]
- regulation of actin cytoskeleton organization [IDA]
- regulation of cell shape [IMP]
- regulation of filopodium assembly [IMP]
- regulation of lamellipodium assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID