BAIT
RAB11B
RAB11B, member RAS oncogene family
GO Process (17)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- cellular component movement [NAS]
- cellular response to acidic pH [ISO, ISS]
- constitutive secretory pathway [IMP, ISO]
- endocytosis [ISO]
- establishment of protein localization to membrane [ISO]
- insulin secretion involved in cellular response to glucose stimulus [ISO, ISS]
- intracellular protein transport [IBA]
- melanosome transport [IBA, ISO, ISS]
- receptor recycling [ISO, ISS]
- regulated secretory pathway [IMP, ISO]
- regulation of anion transport [ISO, ISS]
- regulation of endocytic recycling [ISO, ISS]
- regulation of protein localization to cell surface [ISO, ISS]
- retrograde transport, endosome to plasma membrane [ISO, ISS]
- transferrin transport [ISO, ISS]
Gene Ontology Molecular Function- GDP binding [IBA, ISO, ISS]
- GTP binding [IBA, ISO, ISS]
- GTPase activity [IBA, ISO, ISS]
- myosin V binding [ISO]
- GDP binding [IBA, ISO, ISS]
- GTP binding [IBA, ISO, ISS]
- GTPase activity [IBA, ISO, ISS]
- myosin V binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SREBF2
SREBP-2, SREBP2, bHLHd2, CTA-250D10.14-005
sterol regulatory element binding transcription factor 2
GO Process (10)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- cellular response to laminar fluid shear stress [NAS]
- lipid metabolic process [TAS]
- negative regulation of cholesterol efflux [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of cholesterol storage [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [IDA]
- response to low-density lipoprotein particle [IEP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- C-8 sterol isomerase activity [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- C-8 sterol isomerase activity [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID