BAIT
TXK
BTKL, PSCTK5, PTK4, RLK, TKL
TXK tyrosine kinase
GO Process (15)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- T cell differentiation [IBA]
- T cell receptor signaling pathway [IBA, ISS]
- activation of phospholipase C activity [ISS]
- adaptive immune response [IBA, ISS]
- cytokine production [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interferon-gamma-mediated signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- receptor binding [IBA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- receptor binding [IBA]
Homo sapiens
PREY
GRB10
GRB-IR, Grb-10, IRBP, MEG1, RSS
growth factor receptor-bound protein 10
GO Process (8)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISS, TAS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of glucose import [ISS]
- negative regulation of glycogen biosynthetic process [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphorylation [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- response to insulin [ISS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID