BAIT
KIFAP3
FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1, RP1-190I16.1
kinesin-associated protein 3
GO Process (8)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- blood coagulation [TAS]
- membrane organization [TAS]
- microtubule-based movement [TAS]
- microtubule-based process [ISS]
- plus-end-directed vesicle transport along microtubule [TAS]
- protein complex assembly [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MOS
MSV
v-mos Moloney murine sarcoma viral oncogene homolog
GO Process (8)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- MAPK cascade [ISS]
- activation of MAPK activity [ISS]
- activation of MAPKK activity [ISS]
- chromatin organization [ISS]
- establishment of meiotic spindle orientation [ISS]
- meiotic spindle organization [ISS]
- negative regulation of metaphase/anaphase transition of meiotic cell cycle [ISS]
- protein autophosphorylation [ISS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID