BAIT
TOMM20
MAS20, MOM19, TOM20, RP4-597N16.2
translocase of outer mitochondrial membrane 20 homolog (yeast)
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APOA1
apolipoprotein A-I
GO Process (44)
GO Function (12)
GO Component (16)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- blood coagulation [TAS]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA, IMP]
- cholesterol import [IMP]
- cholesterol metabolic process [IMP]
- cholesterol transport [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IC]
- high-density lipoprotein particle remodeling [IC]
- integrin-mediated signaling pathway [IDA]
- lipoprotein metabolic process [TAS]
- negative chemotaxis [IDA]
- negative regulation of cell adhesion molecule production [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [IDA]
- negative regulation of interleukin-1 beta secretion [IDA]
- negative regulation of response to cytokine stimulus [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- negative regulation of very-low-density lipoprotein particle remodeling [IDA]
- peptidyl-methionine modification [IDA]
- phosphatidylcholine biosynthetic process [IDA]
- phospholipid efflux [IDA]
- phospholipid homeostasis [IDA]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of hydrolase activity [IDA]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- protein oxidation [IDA]
- protein stabilization [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [IDA]
- transmembrane transport [TAS]
- triglyceride homeostasis [IDA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endocytic vesicle [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum lumen [TAS]
- extracellular region [TAS]
- extracellular space [IDA, ISS]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- plasma membrane [TAS]
- secretory granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID