BAIT
TUBB3
CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4
tubulin, beta 3 class III
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
INSM1
IA-1, IA1
insulinoma-associated 1
GO Process (16)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- adrenal chromaffin cell differentiation [ISS]
- endocrine pancreas development [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- noradrenergic neuron development [ISS]
- norepinephrine biosynthetic process [ISS]
- pancreatic A cell differentiation [ISS]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cell differentiation [ISS]
- positive regulation of neural precursor cell proliferation [ISS]
- regulation of gene expression [ISS]
- regulation of protein complex assembly [IDA]
- sympathetic ganglion development [ISS]
- transdifferentiation [IDA]
- type B pancreatic cell differentiation [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- cyclin binding [IPI]
- histone deacetylase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- cyclin binding [IPI]
- histone deacetylase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID